Stem Cells

The California Institute for Regenerative Medicine awarded Stanford researcher Crystal Mackall a grant to study immune cells genetically modified to attack two proteins on leukemia and lymphoma cells.

A subset of liver cells with high levels of telomerase renews the organ during normal cell turnover and after injury, according to Stanford researchers. The cells may also give rise to liver cancer.

Young, resting neural stem cells have large protein clumps often associated with neurodegeneration. As stem cells age, the aggregates inhibit their ability to make new neurons, Stanford researchers say.

In a clinical trial, participants were given an antibody to CD117, a cell surface marker, in an effort to wipe out their defective blood stem cells without high-risk chemotherapy or radiation.

Priming the immune system with induced pluripotent stem cells prevented or slowed the development of cancer in mice, Stanford researchers found.

Three Stanford faculty members were awarded $6 million to support research into a blistering skin disease, transplanted stem cells and novel ways to grow blood stem cells.

New discoveries about the circadian-clock machinery in the precursors to fat cells may explain why shift workers are prone to metabolic diseases, such as diabetes, a Stanford study finds.

The Stanford research suggests that any conclusions about stem cell function based on studies of stem cells in lab dishes may now need to be reconsidered in light of the fact that the cells’ biology changes during isolation.

Stanford scientists have found a cell that creates the two different compartments in the mouse lung. They hope their discovery could lead to better therapies for people with lung disease.

“Humanized” mice are used to study human immune responses, but they are inadequate for stem cell studies, say Stanford researchers. Optimized models are needed for clinical decision-making.

Stanford researchers have found that a metabolite stimulates mouse muscle stem cells to proliferate after injury, and anti-inflammatory drugs, frequently taken after exercise, block its production and inhibit muscle repair.